ABSTRACT
Background: alopecia Areata is a prevalent inflammatory chronic disease which %2 of general population is suffering from it. All current therapies of the disease have their own limitations, so the object of this study is to evaluate efficacy of combination therapy with local %0.5 Antralin and %2 minoxidil solution in treatment of alopecia areata
Materials and Methods: in this placebo-controlled clinical trial, 53 subjects were included. 26 patients received combination therapy for 30 days, they used local %0.5 antralin 20 on their lesions 20 minutes every night, and after washing and drying the area used %2 minoxidil solution the same night and next morning. The rest 27 patients used placebo on their lesions. At the end of study, their hair growth were measured by assessing terminal hair growth
Results: there were 53 subjects with mean age of 18.35±4.23 [%60.4] of the patients were men and the rest %39.6 were women. The drug were more effective than the placebo [%67.9 vs %32.1, P=0.063].Erythema and hyperpigmentation were seen in %96.1 and %100 of patients receiving drug, respectively, while just %29.6 of the placebo group had erythema and no one had hyperpigmentation
Conclusions: most patients who used combination therapy took benefit of the drug and it seems that by increasing number of subjects and continuing the treatment, the rate of efficacy will increase considerably